To this day, medical aesthetic treatments for the improvement of skin quality have been carried out using cocktails based on inert substances to nourish the cells and hydrate the skin. Today, the introduction of products based on polynucleotides represents an absolute innovation, promising to revolutionise rejuvenation. Polynucleotides have various functions: they increase the hydration of the skin layers and protect the cells from oxidative stress thanks to their chemical structure above all.  Moreover, they have a unique characteristic: they bind to specific receptors present in cells, triggering metabolic mechanisms which lead to an increase of collagen, elastin, and endogenous hyaluronic acid. For this reason, polynucleotides are defined as bio-restructuring compounds, that not only nourish and protect cells, but above all stimulate an increase in production and efficient reproduction thus considerably reducing the ageing process.

But let’s see in detail what these substances are and why they are so precious for our skin. Polynucleotides are bioactive molecules present in the nucleus of all living cells, they constitute the DNA and regulate the biological processes of every living cell. They represent a source of information for all cells, the handbook on which all the information for the perfect functioning of cellular life is reported. They are normally extracted from biological matrices (organic origin), purified through specific purification technologies known as HPT (Highly Purified Technology) and transformed into gels with different molecular weights and different concentrations.  Recent Scientific studies have also demonstrated the high ability of polynucleotides to improve healing, and for this reason, they are recommended as pre-surgical preventive treatments to improve and reduce scars.

The essence of aesthetic medicine lies in the pursuit of enhancing our client’s natural beauty, promoting youthfulness, and restoring vitality. Treatments like botox and fillers definitely have their place and audience but there are clients who look to enhance their natural tissue and for those clients nucleotides are a wonderful alternative. Covalently-bonded nucleotide monomers, with their exquisite ability to engage in chemical bonding, bring a new dimension of precision and efficacy to these endeavors. Through their remarkable molecular structure, they possess an unparalleled capacity to interact with and influence the biological processes that underlie our skin’s health and appearance.

By harnessing the power of these covalent bonds, aesthetic practitioners can now introduce nucleotide monomers to the dermal layers thus opening a plethora of possibilities, from stimulating collagen production and improving skin elasticity to enhancing cellular repair mechanisms and promoting overall rejuvenation. The carefully orchestrated interplay between these nucleotide monomers and the intricate cellular machinery within our skin serves as a catalyst for transformation, turning back the hands of time.

The beauty of covalently-bonded nucleotide monomers lies not only in their extraordinary transformative potential but also in their compatibility with the body’s natural processes. These compounds seamlessly integrate into the intricate web of biological pathways, fostering harmony rather than disruption. By mimicking the molecular structures found within our own genetic blueprint, nucleotide monomers are able to communicate with our cells on an intimate level, coaxing them into revealing their inherent luminosity.

The market is full of bio-revitalising products, but it is worth emphasising two products in particular. With formulations dominated by polynucleotides with the addition of hyaluronic acid, vitamins and coenzymes to increase quality and efficacy.

The Nucleofill line is a range of products based on highly purified nucleotides which vary in concentration and molecular weight. The range is comprised of four different products designed to effectively treat the various problems related to skin ageing. From the eye area to the neck and from the face to the hands, additionally, the formulation is suitable for the reduction of incipient hair loss and counteracting bulbar thinning.